The structure of prion: is it enough for interpreting the diverse phenotypes of prion diseases?
نویسندگان
چکیده
Prion diseases, or transmissible spongiform encephalopathies, are neurodegenerative diseases, which affect human and many species of animals with 100% fatality rate. The most accepted etiology for prion disease is 'prion', which arises from the conversion from cellular PrP(C) to the pathological PrP(Sc). This review discussed the characteristic structure of PrP, including PRNP gene, PrP(C), PrP(Sc), PrP amyloid, and prion strains.
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ورودعنوان ژورنال:
- Acta biochimica et biophysica Sinica
دوره 45 6 شماره
صفحات -
تاریخ انتشار 2013